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Chemical Structure : ML-264
CAS No.: 1550008-55-3
Catalog No.: PC-45778Not For Human Use, Lab Use Only.
ML-264 (ML 264) is a potent, selective of KLF5 expression inhibtor, withour effect on kinases associated with the KLF5 pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML-264 (ML 264) is a potent, selective of KLF5 expression inhibtor, withour effect on kinases associated with the KLF5 pathway.
ML-264 inhibits the proliferation of DLD-1 cells with IC50 of 29 nM, and several other KLF5-expressing cell types as well HCT116, IC50 560 nM; HT29, IC50=130 nM; SW620, IC50=430 nM).
ML-264 potently inhibits proliferation of colorectal cancer cells in vitro through modifications of the cell-cycle profile.
ML-264 efficiently inhibits growth of the tumo in an established xenograft mouse model of colon cancer.
| M.Wt | 384.8777 | |
| Formula | C17H21ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propenamide,3-(3-chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-,(2E)- |
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1. Bialkowska A, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Ruiz de Sabando A, et al. Mol Cancer Ther. 2016 Jan;15(1):72-83.
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