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Chemical Structure : ML389
Catalog No.: PC-62116Not For Human Use, Lab Use Only.
ML389 is a highly potent, selective vasopressin receptor 1a (V1a-R) antagonist with IC50 of 40 nM.
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ML389 is a highly potent, selective vasopressin receptor 1a (V1a-R) antagonist with IC50 of 40 nM.
ML389 dispalys >1,250-fold selectivity over V1b-R, V2-R, and OXTR.
ML389 has good brain penetration, no significant activity at four human cytochrome P450 subtypes, high binding for human and rodent plasma protein, and an encouraging in vivo pharmacokinetic profile in mice.
| M.Wt | 404.33 | |
| Formula | C21H23Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mittapalli G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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