Chemical Structure : ML471
CAS No.:
2226227-77-4
ML471
(ML-471)
Catalog No.: PC-23599Not For Human Use, Lab Use Only.
ML471 is a potent, selective reaction hijacking inhibitor of P.falciparum tyrosine tRNA synthetase (PfTyrRS, PfYRS), inhibits growth of asexual blood stage P. falciparum (3D7 strain) in a 72-h exposure assay with IC50 of 2.8 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ML471 is a potent, selective reaction hijacking inhibitor of P.falciparum tyrosine tRNA synthetase (PfTyrRS, PfYRS), inhibits growth of asexual blood stage P. falciparum (3D7 strain) in a 72-h exposure assay with IC50 of 2.8 nM.
ML471 has no inhibitory activity against human ubiquitin-activating enzyme (UAE) in vitro.
ML471 exhibits low nanomolar activity against asexual blood stage P. falciparum and potent activity against liver stage parasites, gametocytes and transmissible gametes.
ML471 is well-tolerated and shows single dose oral efficacy in the SCID mouse model of P. falciparum malaria.
Physicochemical Properties
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M.Wt
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388.40
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Formula
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C13H20N6O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2R,3S,4R,5R)-5-(4-amino-3-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate
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References
1. Xie SC, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012429.
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