Chemical Structure : ML901
CAS No.:
2226228-02-8
ML901
(ML-901)
Catalog No.: PC-23600Not For Human Use, Lab Use Only.
ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM.
ML901 targets PfYRS and inhibits protein translation, by a reaction-hijacking mechanism.
ML901 retained activity against all strains of P. falciparum tested, regardless of their resistance profile and geographical origin.
ML901 triggers eIF2α phosphorylation in wildtype P. falciparum (Cam3.II_rev).
ML901 exerts activity against human Atg7 (IC50 = 33 nM), but has much weaker activity against other E1 enzymes.
ML901 single dose (50 mg/kg i.p.) exhibits in vivo antimalarial efficacy oin severe combined immune deficient (SCID) mice, engrafted with P. falciparum infected human RBCs.
Physicochemical Properties
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M.Wt
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412.32
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Formula
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C11H14F2N6O7S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2R,3S,4R,5R)-5-(4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate
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References
1. Xie SC, et al. Science. 2022 Jun 3;376(6597):1074-1079.
2. Xie SC, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012429.
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