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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-MR120
MR120

Chemical Structure : MR120

CAS No.: 588674-64-0

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MR120 (MR-120, CCR6 antagonist 1b)

Catalog No.: PC-49306Not For Human Use, Lab Use Only.

MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells.

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10 mg $98 In stock
25 mg $158 In stock
50 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells.
MR120 (50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration.
MR120 (30 nM-300 μM) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively.
MR120 (1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice, shows anti-inflammatory effects
in Zymosan-induced peritonitis mice.
MR120 is a first-in-class inhibitor for IBDs targeting the CCL20/CCR6 axis.

Physicochemical Properties

M.Wt 319.283
Formula C17H12F3NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-2-carboxamide

References

1. Maria Grazia Martina, et al. Eur J Med Chem. 2022 Aug 29;243:114703.
2. Allodi M, et al. Eur J Pharmacol. 2023 Feb 23:175613.

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