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MUT-056399

Chemical Structure : MUT-056399

CAS No.: 1269055-85-7

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MUT-056399 (FAB-001)

Catalog No.: PC-45426Not For Human Use, Lab Use Only.

A novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.

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10 mg $400 In stock
50 mg $1200 In stock
100 mg $1680 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli; shows activity against S. aureus strains, including MSSA, MRSA, linezolid-resistant, and multidrug-resistant strains with MIC90s of 0.03-0.12 ug/ml; also has active against coagulase-negative staphylococci with MIC90s of 0.12-4 ug/ml; active in vivo (19.3-49.6 mg/kg/day).

Bacterial Infection

Preclinical

Physicochemical Properties

M.Wt 293.2654
Formula C15H13F2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

Benzamide, 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluoro-

References

1. Escaich S, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.

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