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Chemical Structure : NAV 2729
CAS No.: 419547-11-8
Catalog No.: PC-60611Not For Human Use, Lab Use Only.
NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.
NAV 2729 shows no inhibitory effects for all other human ARF family members, as well as other small GTPases, such as RhoA, Rac1, H-Ras, and Cdc42 (IC50>50 uM).
NAV 2729 inhibits all known signaling pathways downstream of oncogenic GNAQ in uveal melanoma cells, including PLC/PKC, Rho/Rac, YAP, and β-catenin.
NAV 2729 reduces uveal melanoma cell proliferation and tumorigenesis in mouse models.
| M.Wt | 456.886 | |
| Formula | C25H17ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-benzyl-3-(4-chlorophenyl)-5-(4-nitrophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
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1. Yoo JH, et al. Cancer Cell. 2016 Jun 13;29(6):889-904.
2. Benabdi S, et al. Biochemistry. 2017 Sep 26;56(38):5125-5133.
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