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Chemical Structure : NF449
CAS No.: 627034-85-9
Catalog No.: PC-49765Not For Human Use, Lab Use Only.
NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
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| 100 mg | Get quote |
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NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.
NF449 antagonizes ATP or alphabeta-methyleneadenosine 5'-trisphosphate-induced inward currents of homomeric rat P2X(1)-P2X(4) receptors or heteromeric P2X(1 + 5) and P2X(2+3) receptors, respectively.
NF449 is less potent at homomeric P2X(2) receptors (IC(50) 47 microM) and homomeric P2X(4) receptors (IC(50) > 300 microM).
| M.Wt | 1505.05 | |
| Formula | C41H24N6Na8O29S8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
sodium 4,4',4'',4'''-((5,5'-(carbonylbis(azanediyl))bis(isophthaloyl))tetrakis(azanediyl))tetrakis(benzene-1,3-disulfonate) |
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1. Hechler B, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):232-43.
2. Kassack MU, et al. Eur J Med Chem. 2004 Apr;39(4):345-57.
3. Hülsmann M, et al. Eur J Pharmacol. 2003 May 30;470(1-2):1-7.
4. Suzuki E, et al. Mol Pharmacol. 2004 Dec;66(6):1738-47.
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