NF449 (NF449 octasodium) | P2X1 antagonist

Chemical Structure : NF449

CAS No.: 627034-85-9

NF449 (NF-449, NF449 octasodium)

Catalog No.: PC-49765Not For Human Use, Lab Use Only.

NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.

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Biological Activity

NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM.
NF449 antagonizes ATP or alphabeta-methyleneadenosine 5'-trisphosphate-induced inward currents of homomeric rat P2X(1)-P2X(4) receptors or heteromeric P2X(1 + 5) and P2X(2+3) receptors, respectively.
NF449 is less potent at homomeric P2X(2) receptors (IC(50) 47 microM) and homomeric P2X(4) receptors (IC(50) > 300 microM).

Physicochemical Properties

M.Wt	1505.05
Formula	C41H24N6Na8O29S8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 4,4',4'',4'''-((5,5'-(carbonylbis(azanediyl))bis(isophthaloyl))tetrakis(azanediyl))tetrakis(benzene-1,3-disulfonate)

References

1. Hechler B, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):232-43.

2. Kassack MU, et al. Eur J Med Chem. 2004 Apr;39(4):345-57.

3. Hülsmann M, et al. Eur J Pharmacol. 2003 May 30;470(1-2):1-7.

4. Suzuki E, et al. Mol Pharmacol. 2004 Dec;66(6):1738-47.

NF449 (NF-449, NF449 octasodium)

Biological Activity

Physicochemical Properties

References

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