NIBR-3049 |CAS:1260181-14-3 Probechem Biochemicals

Chemical Structure : NIBR-3049

NIBR-3049 (TCS 21311, NIBR3049)

Catalog No.: PC-62972Not For Human Use, Lab Use Only.

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively..

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Biological Activity

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.

Physicochemical Properties

M.Wt	526.51
Formula	C27H25F3N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

References

1. Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8.

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NIBR-3049 (TCS 21311, NIBR3049)

Biological Activity

Physicochemical Properties

References

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