NKH 477 hydrochloride |CAS:138605-00-2 Probechem Biochemicals

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Chemical Structure : NKH 477 hydrochloride

NKH 477 hydrochloride (Colforsin dapropate)

Catalog No.: PC-62254Not For Human Use, Lab Use Only.

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.

Heart Failure

Approveed

Physicochemical Properties

M.Wt	546.1
Formula	C27H43NO8.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride

References

1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.

2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.

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NKH 477 hydrochloride (Colforsin dapropate)

Biological Activity

Physicochemical Properties

References

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