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Chemical Structure : NMS-P715
CAS No.: 1202055-32-0
Catalog No.: PC-43014Not For Human Use, Lab Use Only.
NMS-P715 is a potent, selective, orally bioavailable Mps1 inhibitor with IC50 of 8 nM, Ki of 0.99 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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NMS-P715 is a potent, selective, orally bioavailable Mps1 inhibitor with IC50 of 8 nM, Ki of 0.99 nM.
NMS-P715 displays excellent selectivity in vitro against a panel of 60 kinases at 5 uM.
NMS-P715 selectively reduces cancer cell proliferation, leaving normal cells almost unaffected, promotes massive spindle assembly checkpoint (SAC) in U2OS cells with EC50 of 68 nM.
NMS-P715 causes a reduction in G1 phase and a flattening in G2/M phase of the cell cycle accompanied by histone H3 dephosphorylation, PARP cleavage, and histone H2AX phosphorylation.
NMS-P715 inhibits tumor growth in preclinical cancer models.
| M.Wt | 676.7311 | |
| Formula | C35H39F3N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 6.9 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide, N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amino]- |
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1. Colombo R, et al. Cancer Res. 2010 Dec 15;70(24):10255-64.
2. Slee RB, et al. Mol Cancer Ther. 2014 Feb;13(2):307-315.
3. Maachani UB, et al. Mol Cancer Res. 2015 May;13(5):852-62.
4. Gurden MD, et al. Cancer Res. 2015 Aug 15;75(16):3340-54.
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