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NS-018

Chemical Structure : NS-018

CAS No.: 1239358-86-1

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NS-018 (NS018, Ilginatinib)

Catalog No.: PC-45663Not For Human Use, Lab Use Only.

NS-018 (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

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10 mg $358 In stock
25 mg $548 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NS-018 (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).
NS-018 displays 30-50-fold greater selectivity for JAK2 over JAK1, JAK3 and Tyk2.
NS-018 also inhibits Src family kinases(Src, Fyn).
NS-018 shows effective in mouse Ba/F3-JAK2V617F disease model.

Physicochemical Properties

M.Wt 389.4288
Formula C21H20FN7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-

References

1. Nakaya Y, et al. Blood Cancer J. 2011 Jul;1(7):e29.

2. Nakaya Y, et al. Blood Cancer J. 2014 Jan 10;4:e174.

3. Kuroda J, et al. Leuk Res. 2014 May;38(5):619-24.

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