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Chemical Structure : NS-018 hydrochloride
CAS No.: 1239358-85-0
Catalog No.: PC-45664Not For Human Use, Lab Use Only.
NS-018 hydrochloride (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).
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|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $348 | In stock | |
| 25 mg | $548 | In stock | |
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| 100 mg | Get quote |
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NS-018 hydrochloride (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).
NS-018 displays 30-50-fold greater selectivity for JAK2 over JAK1, JAK3 and Tyk2.
NS-018 also inhibits Src family kinases(Src, Fyn).
NS-018 shows effective in mouse Ba/F3-JAK2V617F disease model.
| M.Wt | 425.8897 | |
| Formula | C21H21ClFN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-, hydrochloride (1:1) |
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1. Nakaya Y, et al. Blood Cancer J. 2011 Jul;1(7):e29.
2. Nakaya Y, et al. Blood Cancer J. 2014 Jan 10;4:e174.
3. Kuroda J, et al. Leuk Res. 2014 May;38(5):619-24.
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