Nx-1607 | Cbl-b inhibitor | Probechem Biochemicals

Chemical Structure : Nx-1607

Nx-1607 (Nx1607, NX-1607)

Catalog No.: PC-21554Not For Human Use, Lab Use Only.

Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.

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Biological Activity

Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
Nx-1607 binds to the TKBD-LHR unit of Cbl-b, locking the protein in an inactive conformation.
Nx-1607 inhibits the interaction between the N-terminal E3 ligase fragment (TKBD-LHR-RING) of Cbl-b and UbcH5B-Ub (E2-Ub) complex in the presence of the Src kinase substrate.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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Nx-1607 (Nx1607, NX-1607)

Biological Activity

Physicochemical Properties

References

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