Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Nx-1607
Catalog No.: PC-21554Not For Human Use, Lab Use Only.
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
Nx-1607 binds to the TKBD-LHR unit of Cbl-b, locking the protein in an inactive conformation.
Nx-1607 inhibits the interaction between the N-terminal E3 ligase fragment (TKBD-LHR-RING) of Cbl-b and UbcH5B-Ub (E2-Ub) complex in the presence of the Src kinase substrate.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
