O-304 | AMPK activator, PCSK9 modulator

Chemical Structure : O-304

CAS No.: 1261289-04-6

O-304 (O304)

Catalog No.: PC-62464Not For Human Use, Lab Use Only.

O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$388	In stock
50 mg	$588	In stock
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Biological Activity

O-304 is a small molecule AMPK activator and PCSK9 modulator, reduces extracellular and secreted PCSK9 levels in human liver cells and reduces PCSK9 plasma levels and total cholesterol levels in obese rats.

Physicochemical Properties

M.Wt	380.243
Formula	C16H11Cl2N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide

References

1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

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O-304 (O304)

Biological Activity

Physicochemical Properties

References

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