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Chemical Structure : ONX-0914
CAS No.: 960374-59-8
Catalog No.: PC-43393Not For Human Use, Lab Use Only.
ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2.
ONX-0914 (PR-957) blocks presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells.
ONX-0914 (PR-957) reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels in experimental arthritis models.
| M.Wt | 580.6719 | |
| Formula | C31H40N4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]- |
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1. Muchamuel T, et al. Nat Med. 2009 Jul;15(7):781-7.
2. Basler M, et al. J Immunol. 2010 Jul 1;185(1):634-41.
3. Ichikawa HT, et al. Arthritis Rheum. 2012 Feb;64(2):493-503.
4. Verbrugge SE, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82.
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