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OTS-514

Chemical Structure : OTS-514

CAS No.: 1338540-63-8

OTS-514 (OTS514)

Catalog No.: PC-45487Not For Human Use, Lab Use Only.

OTS-514 (OTS514) is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OTS-514 (OTS514) is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM.
OTS-514 shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition).
OTS-514 strongly suppresses the growth of TOPK-positive cancer cells.
OTS-514 demonstrates in vivo efficacy but causes severe hematopoietic toxicity.

Physicochemical Properties

M.Wt 364.4607
Formula C21H20N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Thieno[2,3-c]quinolin-4(5H)-one, 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-

References

1. Matsuo Y, et al. Sci Transl Med. 2014 Oct 22;6(259):259ra145.

2. Alachkar H, et al. Oncotarget. 2015 Oct 20;6(32):33410-25.

3. Kato T, et al. Oncotarget. 2016 Apr 5;7(14):17652-64.

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