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Chemical Structure : OTS-514
CAS No.: 1338540-63-8
Catalog No.: PC-45487Not For Human Use, Lab Use Only.
OTS-514 (OTS514) is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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OTS-514 (OTS514) is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM.
OTS-514 shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition).
OTS-514 strongly suppresses the growth of TOPK-positive cancer cells.
OTS-514 demonstrates in vivo efficacy but causes severe hematopoietic toxicity.
| M.Wt | 364.4607 | |
| Formula | C21H20N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Thieno[2,3-c]quinolin-4(5H)-one, 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl- |
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1. Matsuo Y, et al. Sci Transl Med. 2014 Oct 22;6(259):259ra145.
2. Alachkar H, et al. Oncotarget. 2015 Oct 20;6(32):33410-25.
3. Kato T, et al. Oncotarget. 2016 Apr 5;7(14):17652-64.
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