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Chemical Structure : Org-26576
CAS No.: 1026791-61-6
Catalog No.: PC-42337Not For Human Use, Lab Use Only.
A potent AMPA receptor positive allosteric modulator.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $208 | In stock | |
| 100 mg | $368 | In stock |
Bulk size, bulk discount!
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A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516; increases neuronal cell proliferation and survival in adult rodent hippocampus; produces nootropic effects in vivo.
Depression
Phase 2 Clinical
| M.Wt | 204.22518 | |
| Formula | C11H12N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5H,7H-Pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one, 8,9,9a,10-tetrahydro-, (9aS)- |
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1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64.
2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.
3. Hamlyn E, et al. Behav Pharmacol. 2009 Oct;20(7):662-7.
4. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.
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