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Chemical Structure : PAT-505
CAS No.: 1782070-85-2
Catalog No.: PC-60638Not For Human Use, Lab Use Only.
PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $288 | In stock | |
| 5 mg | $488 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
PAT-505 displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ.
PAT-505 maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively.
PAT-505 robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.
| M.Wt | 495.905 | |
| Formula | C23H17ClF2N3NaO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl) thio)-2-fluorobenzoic acid sodium salt |
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1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.
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