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Chemical Structure : PCI-24781
CAS No.: 783355-60-2
Catalog No.: PC-42767Not For Human Use, Lab Use Only.
PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM.
PCI-24781 also inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range.
PCI-24781 causes the accumulation of acetylated histone and acetylated tubulin in tumor cell lines.
PCI-24781 decreases RAD51 expression and inhibits homologous recombination.
| M.Wt | 397.4244 | |
| Formula | C21H23N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]- |
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1. Buggy JJ, et al. Mol Cancer Ther. 2006 May;5(5):1309-17.
2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.
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