PD-146176 (NSC 168807, PD146176) is a potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM.
PD-146176 shows no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2.
PD-146176 significantly abrogates SAT1-induced ferroptosis, inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.
Physicochemical Properties
M.Wt
237.3
Formula
C15H11NS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
References
1. Ou Y, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6806-E6812., et al.
2. Bocan TM, et al. Atherosclerosis. 1998 Feb;136(2):203-16.
3. Sendobry SM, et al. Br J Pharmacol. 1997 Apr;120(7):1199-206.
