Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-PD-184352
PD-184352

Chemical Structure : PD-184352

CAS No.: 212631-79-3

Add to Favorites

PD-184352 (CI-1040, PD184352)

Catalog No.: PC-45828Not For Human Use, Lab Use Only.

PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $148 In stock
50 mg $258 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
PD-184352 reduces pMAPK levels in multiple tumor cells, prevents cell cycle progression and induces G1 block.
PD-184352 suppresses growth of colon tumors in vivo.

Physicochemical Properties

M.Wt 478.6595
Formula C17H14ClF2IN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 150 mg/mL
Chemical Name/SMILES

Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-

References

1. Sebolt-Leopold JS, et al. Nat Med, 1999, 5(7), 810-816.

2. Davies SP, et al. Biochem J, 2000, 135(1), 95-105.

3. Pellicano F, et al. Leukemia, 2011, 25(7), 1159-1167.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: