Catalog No.: PC-60958Not For Human Use, Lab Use Only.
PF-00337210 is a potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively.
PF-00337210 is a potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively.
PF-00337210 inhibits the autophosphorylation of human and murine VEGFR-2 with IC50 of 0.87 nM and 0.83 nM, respectively.
PF-00337210 is less potent against KIT (9.6 nM), CSF1-R (13 nM), PDGFR-α (11 nM) and PDGFR-β (29 nM), and does not inhibit Flt-3 (>10 uM).
PF-00337210 shows dose-dependent anti-tumor efficacy in preclinical tumor models.
