Chemical Structure : PF-04971729
CAS No.: 1210344-57-2
Catalog No.: PC-44436Not For Human Use, Lab Use Only.
A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.
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10 mg | $176 | In stock | |
50 mg | $528 | In stock |
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A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2; shows >2000-fold selectivity over hSGLT1; demonstrates robust urinary glucose excretion in rats and an excellent preclinical safety profile.
Diabetes
Phase 3 Clinical
M.Wt | 436.8827 | |
Formula | C22H25ClO7 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 46 mg/mL |
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Chemical Name/SMILES |
β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)- |
1. Mascitti V, et al. J Med Chem. 2011 Apr 28;54(8):2952-60.
2. Kalgutkar AS, et al. Drug Metab Dispos. 2011 Sep;39(9):1609-19.
3. Miao Z, et al. Drug Metab Dispos. 2013 Feb;41(2):445-56.
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