Chemical Structure : PF-7006
CAS No.:
2771955-09-8
PF-7006
(PF7006)
Catalog No.: PC-21557Not For Human Use, Lab Use Only.
PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.
PF-7006 triggers signaling events consistent with mitotic checkpoint abrogation.
PF-7006 at 25 mg/kg inhibited tuomor growth in the HCC1806 triple-negative breast cancer model.
PF-7006 inhibitor-induced cytotoxicity as function of retinoblastoma tumor suppressor protein (Rb1) status in tHMEC cultures co-treated with the CDK4/6 inhibitor palabociclib.
PF-7006 is shown to be selectively cytotoxic to Rb1-deficient cells relative to Rb1-competent cells.
Physicochemical Properties
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M.Wt
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434.50
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Formula
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C22H26N8O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2-methyl-6-morpholinopyridin-3-yl)amino)-4-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
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References
1. Ricardo Martinez, et al. PLoS One. 2015 Sep 23;10(9):e0138616.
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