Catalog No.: PC-43508Not For Human Use, Lab Use Only.
PF-8380 is a potent, specific, orally active Autotaxin inhibitor with IC50 of 2.8 and 101 nM in enzyme assay and in human whole blood assay, respectively.
PF-8380 is a potent, specific, orally active Autotaxin inhibitor with IC50 of 2.8 and 101 nM in enzyme assay and in human whole blood assay, respectively.
PF-8380 produces >95% reduction in both plasma and air pouch lysophosphatidic acid (LPA) within 3 h by dosed orally at 30 mg/kg in rat air pouch model.
PF-8380 reduces inflammatory hyperalgesia in vivo.
PF-8380 also enhances the radiosensitivity of human and murine glioblastoma cell lines.
