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Chemical Structure : PF0346275
Catalog No.: PC-61458Not For Human Use, Lab Use Only.
A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM).
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A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM); demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg).
| M.Wt | 376.86 | |
| Formula | C19H22ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6.
2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640.
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