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PF670462

Chemical Structure : PF670462

CAS No.: 950980-98-0

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PF670462 (PF-670462)

Catalog No.: PC-49496Not For Human Use, Lab Use Only.

PF-670462 (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively, causes a significant phase delay in animal models of circadian rhythm.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-670462 (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively, causes a significant phase delay in animal models of circadian rhythm.

    Physicochemical Properties

    M.Wt 337.40
    Formula C19H20FN5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine

    References

    1. Badura L, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8.

    2. Bryant CD, et al. Psychopharmacology (Berl). 2009 May;203(4):703-11.

    3. Walton KM, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.

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