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PF670462

Chemical Structure : PF670462

CAS No.: 950980-98-0

PF670462 (PF-670462)

Catalog No.: PC-49496Not For Human Use, Lab Use Only.

PF-670462 (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively, causes a significant phase delay in animal models of circadian rhythm.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-670462 (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively, causes a significant phase delay in animal models of circadian rhythm.

Physicochemical Properties

M.Wt 337.40
Formula C19H20FN5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine

References

1. Badura L, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8.

2. Bryant CD, et al. Psychopharmacology (Berl). 2009 May;203(4):703-11.

3. Walton KM, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.

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