Catalog No.: PC-42915Not For Human Use, Lab Use Only.
PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.
PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.
PFK15 (PFK 015) does not inhibit PFK-1, hexokinase, phosphoglucose isomerase and PFKFB4, and has no activity against a panel of 96 kinases.
PFK15 (PFK 015) inhibits cancer cell viability (H522 cell IC50=0.72 uM) and induces apoptosis.
PFK15 (PFK 015) suppresses the glucose uptake and exhibits antitumor effects in human xenograft models.
Physicochemical Properties
M.Wt
260.29
Formula
C17H12N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 25.2 mg/mL
Chemical Name/SMILES
2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-
References
1. Clem BF, et al. Mol Cancer Ther. 2013 Aug;12(8):1461-70.
2. Lea MA, et al. Anticancer Res. 2016 Apr;36(4):1479-88.
3. Zhu W, et al. PLoS One. 2016 Sep 26;11(9):e0163768.
4. Li HM, et al. J Exp Clin Cancer Res. 2017 Jan 7;36(1):7.
