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Chemical Structure : PG-S3-001
Catalog No.: PC-63081Not For Human Use, Lab Use Only.
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
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PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
PG-S3-001 shows no effect in a kinome screen (>100 cancer-relevant kinases).
PG-S3-001 inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range.
PG-S3-001 exhibits in vivo efficacy on pancreatic cancer xenografts.
| M.Wt | 652.677 | |
| Formula | C32H33F5N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
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