PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
PHPS1 displays 8- and 15-fold selectivity against most closely related PTPs, PTP1B, and Shp1.
PHPS1 (5 μM) inhibits HGF/SF-induced scattering and branching morphogenesis of MDCK epithelial cells.
PHPS1 inhibits Shp2-dependent signaling pathways, inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner in MDCK cells.
PHPS1 effectively inhibits anchorage-independent growth of human tumor cells, which correlates strongly with their tumorigenicity and invasiveness.
Physicochemical Properties
M.Wt
487.42
Formula
C21H14N5NaO6S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Benzenesulfonic acid, 4-[(1E)-2-[4,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4-yl]diazenyl]-, sodium salt (1:1)
References
1. Klaus Hellmuth, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80.
