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PI5P4K inhibitor 13

Chemical Structure : PI5P4K inhibitor 13

CAS No.: 2428737-31-7

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PI5P4K inhibitor 13

Catalog No.: PC-38271Not For Human Use, Lab Use Only.

PI5P4K inhibitor 13 is a selective pan-PI5P4K covalent inhibitor with IC50 of 2.0/13 uM against PI5P4Kα/β, 100% inhibition of PI5P4Kγ at 1 uM (Kd=3.4 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PI5P4K inhibitor 13 is a selective pan-PI5P4K covalent inhibitor with IC50 of 2.0/13 uM against PI5P4Kα/β, 100% inhibition of PI5P4Kγ at 1 uM (Kd=3.4 nM).

    Physicochemical Properties

    M.Wt 363.435
    Formula C20H17N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide

    References

    1. Helen K Boffey, et al. J Med Chem. 2022 Feb 11. doi: 10.1021/acs.jmedchem.1c01819.

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