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Chemical Structure : PK-11195
CAS No.: 85340-56-3
Catalog No.: PC-60185Not For Human Use, Lab Use Only.
PK-11195 (PK 11195) is an isoquinoline carboxamide that binds selectively to PBR (TSPO) with Ki of 3.1 nM in cerebellum, 4.1 nM in spinal cord.
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|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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PK-11195 (PK 11195) is an isoquinoline carboxamide that binds selectively to PBR (TSPO) with Ki of 3.1 nM in cerebellum, 4.1 nM in spinal cord.
PK-11195 blocks binding of typical benzodiazepines to TSPO, inhibits proliferation.
PK-11195 induces apoptosis and causes G 1/S cell cycle arrest in NB cell lines at micromolar concentrations.
| M.Wt | 352.87 | |
| Formula | C21H21ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide |
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1. Watanabe Y, et al. Jpn J Pharmacol. 1986 Oct;42(2):189-97.
2. Olson JM, et al. Cancer Res. 1988 Oct 15;48(20):5837-41.
3. Mendonça-Torres MC, et al. Cancer Biol Ther. 2013 Apr;14(4):319-26.
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