Chemical Structure : PK-11195
CAS No.:
85340-56-3
PK-11195
(PK11195, PK 11195, (R)-PK11195)
Catalog No. : PC-60185Not For Human Use, Lab Use Only.
PK-11195 (PK 11195) is an isoquinoline carboxamide that binds selectively to PBR (TSPO) with Ki of 3.1 nM in cerebellum, 4.1 nM in spinal cord.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6018501
Biological Activity
PK-11195 (PK 11195) is an isoquinoline carboxamide that binds selectively to PBR (TSPO ) with Ki of 3.1 nM in cerebellum, 4.1 nM in spinal cord.
Physicochemical Properties
M.Wt
352.87
Formula
C21H21ClN2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(R)-1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide
References
1. Watanabe Y, et al. Jpn J Pharmacol. 1986 Oct;42(2):189-97.
2. Olson JM, et al. Cancer Res. 1988 Oct 15;48(20):5837-41.
3. Mendonça-Torres MC, et al. Cancer Biol Ther. 2013 Apr;14(4):319-26.
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