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Chemical Structure : PLB-1001
CAS No.: 1440964-89-5
Catalog No.: PC-35732Not For Human Use, Lab Use Only.
PLB-1001 (Bozitinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $128 | In stock | |
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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PLB-1001 (Bozitinib, Vebreltinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM.
Similar with crizotinib, PLB-1001 inhibited the phosphorylation of MET and STAT3, indicating a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways.
PLB-1001 demonstrates remarkable potency in selectively inhibiting MET-altered tumor cells (METex14) in preclinical models.
PLB-1001 also exhibits clinical potential for precisely treating gliomas.
| M.Wt | 424.391 | |
| Formula | C20H15F3N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine |
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1. Hu H, et al. Cell. 2018 Oct 12. pii: S0092-8674(18)31250-9.
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