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Chemical Structure : PLX-7904
CAS No.: 1393465-84-3
Catalog No.: PC-45594Not For Human Use, Lab Use Only.
A potent and selective BRaf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $216 | In stock | |
| 50 mg | $960 | In stock | |
| 100 mg | $1680 | In stock |
Bulk size, bulk discount!
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A potent and selective BRaf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells; inhibits the growth of A375, COLO829, COLO205 that expresses BRAFV600E with IC50 values of 0.17 uM, 0.53 uM, and 0.16 uM, respectively; inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells.
| M.Wt | 512.5317 | |
| Formula | C24H22F2N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl- |
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1. Zhang C, et al. Nature. 2015 Oct 22;526(7574):583-6.
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