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Chemical Structure : PRN-1371
CAS No.: 1802929-43-6
Catalog No.: PC-60073Not For Human Use, Lab Use Only.
PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.
PRN-1371 demonstrates excellent kinome-wide selectivity in a number of biochemical and cellular assays.
PRN-1371 exhibits sustained inhibition of FGFR in multiple tumor xenografts and patient-derived tumor xenograft models.
| M.Wt | 561.464 | |
| Formula | C26H30Cl2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one |
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1. Brameld KA, et al. J Med Chem. 2017 Aug 10;60(15):6516-6527.
2. Venetsanakos E, et al. Mol Cancer Ther. 2017 Dec;16(12):2668-2676.
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