Catalog No.: PC-60073Not For Human Use, Lab Use Only.
PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.
PRN-1371 (PRN1371) is a potent, selective, irreversible covalent, orally active pan-FGFR inhibitor with IC50 of 0.6/1.3/4.1/19.3 nM for FGFR1/2/3/4, respectively.
PRN-1371 demonstrates excellent kinome-wide selectivity in a number of biochemical and cellular assays.
PRN-1371 exhibits sustained inhibition of FGFR in multiple tumor xenografts and patient-derived tumor xenograft models.
