PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.
PU-H71 inhibits cell growth in a range of breast cancer cell lines with IC50 values of 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells, respectively.
PU-H71 inhibits cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
PU-H71 demonstrated anti-lymphoma activity and showed synergistic effect with dual PI3K/mTOR inhibition in vitro and in vivo.
