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Pagoclone

Chemical Structure : Pagoclone

CAS No.: 133737-32-3

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Pagoclone ((+)-RP-59037, IP-456, RP-62955, CI-1043)

Catalog No.: PC-42414Not For Human Use, Lab Use Only.

Pagoclone ((+)-RP-59037, IP-456) is a potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pagoclone ((+)-RP-59037, IP-456) is a potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit.
Pagoclone ((+)-RP-59037, IP-456) exhibits significant anxiolytic-like activity in vivo.

Physicochemical Properties

M.Wt 407.89268
Formula C23H22ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Isoindol-1-one, 2-(7-chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-(5-methyl-2-oxohexyl)-, (+)-

References

1. Atack JR. Expert Opin Investig Drugs. 2005 May;14(5):601-18.

2. Atack JR, et al. Neuropharmacology. 2006 May;50(6):677-89.

3. Caveney AF, et al. Neuropsychiatr Dis Treat. 2008 Feb;4(1):277-82.

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