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Chemical Structure : Picropodophyllotoxin
CAS No.: 477-47-4
Catalog No.: PC-49763Not For Human Use, Lab Use Only.
Picropodophyllotoxin (AXL1717, PPT) is a selective orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor with IC50 of 1 nM, no activity against insulin receptor, FGFR, PDGFR or EGFR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | $588 | In stock | |
| 1 g | Get quote |
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Picropodophyllotoxin (AXL1717, PPT) is a selective orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor with IC50 of 1 nM, no activity against insulin receptor, FGFR, PDGFR or EGFR.
Picropodophyllin (AXL1717) (0.5-10 μM) potently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation in intact cells.
Picropodophyllin (AXL1717) inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells.
Picropodophyllin (AXL1717) synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199.
Picropodophyllin (AXL1717) (20 mg/kg, i.p.) causes complete tumor regression in SCID mice xenografted with human ES-1, BE, and PC3, increases survival in the 5T33MM mouse model.
| M.Wt | 414.41 | |
| Formula | C22H22O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one |
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1. Menu E, et al. Blood. 2006 Jan 15;107(2):655-60.
2. Vasilcanu D, et al. Oncogene. 2004 Oct 14;23(47):7854-62.
3. Menu E, et al. Int J Cancer. 2007 Oct 15;121(8):1857-61.
4. Girnita A, et al. Cancer Res. 2004 Jan 1;64(1):236-42.
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