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Chemical Structure : Procaspase-3 activator PAC‐1
CAS No.: 315183-21-2
Catalog No.: PC-22740Not For Human Use, Lab Use Only.
PAC-1 is a small-molecule activator of procaspase-3 to caspase-3, induces apoptosis in cancerous cells, induces apoptosis in HL-60 cells with EC50 of 2.08 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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PAC-1 is a small-molecule activator of procaspase-3 to caspase-3, induces apoptosis in cancerous cells, induces apoptosis in HL-60 cells with EC50 of 2.08 uM.
PAC-1 induces death in cells isolated from freshly resected colon tumors.
PAC-1 significantly retards tumor growth in mouse models of cancer.
PAC-1 strongly activates procaspase-3 in buffers that contain zinc.
| M.Wt | 392.50 | |
| Formula | C23H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide |
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1. Putt KS, et al. Nat Chem Biol. 2006 Oct;2(10):543-50.
2. Peterson QP, et al. J Mol Biol. 2009 Apr 24;388(1):144-58.
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