Catalog No.: PC-35829Not For Human Use, Lab Use Only.
QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.
QM385 (QM-385) is an orally available, potent, specific sepiapterin reductase (SPR) inhibitor (binding IC50=1.49 nM) to limit tetrahydrobiopterin (BH4) production, effectively inhibits the proliferation of human CD4+ T cells.
QM385 is structurally distinct from SPRi3, does not inhibit a panel of physiologically important targets or closely related reductases.
QM385 potently inhibits BH4 levels in anti-CD3/28-stimulated mouse splenocytes and human PBMCs with IC50 of 35 nM and 74 nM respectively.
QM385 treatment resulted in markedly less proliferation of CD4+ T cells in vitro, oral administration of QM385 to mice for 3 days greatly reduced the number of inflammatory T cells and eosinophils in the ovalbumin-induced and house dust mite (HDM) airway allergic inflammation models.
