Catalog No.: PC-42880Not For Human Use, Lab Use Only.
R406 is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM.
R406 (Tamatinib) is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM.
R406 displays 5- to 100-fold selectivity over a panel of 90 kinases, no activity against Lyn kinase.
R406 does not inhibit phosphorylation of Syk tyrosine 352 but inhibited the phosphorylation of LAT tyrosine 191, inhibits the anti-IgE-induced production and release of LTC4 and cytokines and chemokines, including TNFα, IL-8, and GM-CSF.
R406 reduces immune complex-mediated inflammation in arthritis models and is orally active.
