Chemical Structure : RAY1216
CAS No.:
2923310-64-7
RAY1216
(Leritrelvir, RAY-1216)
Catalog No.: PC-22071Not For Human Use, Lab Use Only.
Leritrelvir (RAY1216) is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 8.4 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Leritrelvir (RAY1216) is a potent, selective peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro) with Ki of 8.4 nM.
RAY1216 displays high potency against different SARS-CoV-2 variants with EC50 of 116 nM (wild type (WT)), 80 nM (Alpha), 88 nM (Beta), 69 nM (Delta), 81 nM (Omicron BA.1), 91 nM (Omicron BA.5) and 135 nM (Omicron XBB.1.9.1).
RAY1216 (150-600 mg/kg) effectively prolonged survival of mice infected with SARS-CoV-2, significantly decreased lung viral titres.
RAY1216 possesses superior drug-target residence time, when compared with PF-07321332 (nirmatrelvir), the active antiviral component in Paxlovid.
Physicochemical Properties
|
M.Wt
|
639.72
|
|
Formula
|
C31H44F3N5O6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
Cyclopenta[c]pyrrole-1-carboxamide, 2-[(2S)-2-cyclohexyl-2-[(2,2,2-trifluoroacetyl)amino]acetyl]-N-[(1S)-3-(cyclopentylamino)-2,3-dioxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]octahydro-, (1S,3aR,6aS)-
|
References
1. Chen X, et al. Nat Microbiol. 2024 Apr;9(4):1075-1088.
Contact Us
sales@probechem.com
