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Chemical Structure : RIP1-IN-22
Catalog No.: PC-62633Not For Human Use, Lab Use Only.
RIP1-IN-22 is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor with pKi of 9.04.
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RIP1-IN-22 is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor with pKi of 9.04; displays excellent specificity for RIP1 kinase over 406 kinases including RIP3 kinase; strongly suppressed necroptotic cell death and phosphorylation of MLKL (pMLKL) in HT-29 cells (nectoptosis; IC50=2.0 nM, pMLKL; IC50 = 1.3 nM) as well as L929 cells (nectoptosis; IC50=15 nM, pMLKL; IC50=2.7 nM); attenuates disease progression in the mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) after oral administration (10 mg/kg, bid).
| M.Wt | 461.906 | |
| Formula | C24H20ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yoshikawa M, et al. J Med Chem. 2018 Feb 27. doi: 10.1021/acs.jmedchem.7b01647.
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