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Chemical Structure : RN-486
CAS No.: 1242156-23-5
Catalog No.: PC-45403Not For Human Use, Lab Use Only.
RN-486 is a potent and selective BTK inhibitor with IC50 of 4 nM in enzymatic assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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RN-486 is a potent and selective BTK inhibitor with IC50 of 4 nM in enzymatic assays.
RN-486 shows high selectivity against a panel of 369 kinases.
RN-486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC50=2.9 nM) and Fcγ receptor engagement-mediated TNFα production in monocytes (IC50=7.0 nM).
RN-486 shows robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models.
| M.Wt | 606.6892 | |
| Formula | C35H35FN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 24 mg/mL |
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| Chemical Name/SMILES |
1(2H)-Isoquinolinone, 6-cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro- |
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1. Xu D, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103.
2. Mina-Osorio P, et al. Arthritis Rheum. 2013 Sep;65(9):2380-91.
3. Lou Y, et al. J Med Chem. 2015 Jan 8;58(1):512-6.
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