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Chemical Structure : RNB-61
Catalog No.: PC-22602Not For Human Use, Lab Use Only.
RNB-61 is a highly potent, selective and orally bioavailable cannabinoid CB2 receptor (CB2R) full agonist with Ki of 0.57/1.33 nM for hCB2R/mCB2R, >5000-fold selective over hCB1R.
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RNB-61 is a highly potent, selective and orally bioavailable cannabinoid CB2 receptor (CB2R) full agonist with Ki of 0.57/1.33 nM for hCB2R/mCB2R, >5000-fold selective over hCB1R.
RNB-61 inhibits the FSK-induced cAMP formation on human CB2R with EC50 of 0.31 nM, and EC50 of 0.29 nM for Q63R human variant.
RNB-61 inhibits the FSK-induced cAMP formation on mouse, rat, dog, and monkey CB2Rs with EC50 values ranging from 0.13 to 1.86 nM.
RNB-61 (0.3-3 mg/kg) exerts protective effects in kidney ischemia reperfusion (I/R) and unilateral ureteral obstruction (UUO) rodent models.
| M.Wt | 481.56 | |
| Formula | C25H34F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent US20100076029A1.
2. Chicca A, et al. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591311.
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