Chemical Structure : RNB-61
CAS No.:
1217403-51-4
RNB-61
(RNB61)
Catalog No.: PC-22602Not For Human Use, Lab Use Only.
RNB-61 is a highly potent, selective and orally bioavailable cannabinoid CB2 receptor (CB2R) full agonist with Ki of 0.57/1.33 nM for hCB2R/mCB2R, >5000-fold selective over hCB1R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RNB-61 is a highly potent, selective and orally bioavailable cannabinoid CB2 receptor (CB2R) full agonist with Ki of 0.57/1.33 nM for hCB2R/mCB2R, >5000-fold selective over hCB1R.
RNB-61 inhibits the FSK-induced cAMP formation on human CB2R with EC50 of 0.31 nM, and EC50 of 0.29 nM for Q63R human variant.
RNB-61 inhibits the FSK-induced cAMP formation on mouse, rat, dog, and monkey CB2Rs with EC50 values ranging from 0.13 to 1.86 nM.
RNB-61 (0.3-3 mg/kg) exerts protective effects in kidney ischemia reperfusion (I/R) and unilateral ureteral obstruction (UUO) rodent models.
Physicochemical Properties
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M.Wt
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481.56
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Formula
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C25H34F3N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(5-(tert-butyl)-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene)-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
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References
1. Patent US20100076029A1.
2. Chicca A, et al. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591311.
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