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Chemical Structure : RO-5126766
CAS No.: 946128-88-7
Catalog No.: PC-45504Not For Human Use, Lab Use Only.
RO-5126766 (CH-5126766, Avutometinib, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $798 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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RO-5126766 (CH-5126766, Avutometinib, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
RO-5126766 (CH-5126766, Avutometinib) shows weak or no inhibition on CYP2C9, CYP3A4 and hERG.
RO-5126766 (CH-5126766, Avutometinib) inhibits ERK signaling output more effectively than a standard MEK inhibitor PD0325901 that induces MEK phosphorylation and has potent antitumor activity as well.
| M.Wt | 471.4615 | |
| Formula | C21H18FN5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Sulfamide, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl- |
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1. Aoki T, et al. ACS Med Chem Lett. 2014 Jan 22;5(4):309-14.
2. Ishii N, et al. Cancer Res. 2013 Jul 1;73(13):4050-60.
3. Wada M, et al. PLoS One. 2014 Nov 25;9(11):e113217.
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