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Chemical Structure : RRX-001
CAS No.: 925206-65-1
Catalog No.: PC-35927Not For Human Use, Lab Use Only.
RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α.
RRX-001 targets CD133 + /CD44 + cancer stem cells from colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc.
RRX-001 inhibits HCT 116 and decreases levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner.
RRX-001 (RRX001) is a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia.
| M.Wt | 268.023 | |
| Formula | C5H6BrN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one |
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1. Reid T, et al. Lancet Oncol. 2015 Sep;16(9):1133-1142. doi: 10.1016/S1470-2045(15)00089-3.
2. Scicinski J, et al. Redox Biol. 2015 Aug;5:422. doi: 10.1016/j.redox.2015.09.035.
3. Kim MM, et al. Transl Oncol. 2016 Apr;9(2):108-113.
4. Oronsky B, et al. Invest New Drugs. 2016 Jun;34(3):371-7.
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