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RU1968

Chemical Structure : RU1968

CAS No.: 171336-24-6

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RU1968 (RU 1968, RU-1968)

Catalog No.: PC-63469Not For Human Use, Lab Use Only.

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.
    RU1968 suppresses progesterone- and prostaglandin-induced Ca2+ signals in human sperm (IC50=4 and 3.8 uM).
    RU1968 potently abolishes CatSper-mediated Ca2+ signals in mouse, human, and sea urchin sperm.

    Physicochemical Properties

    M.Wt 370.581
    Formula C24H38N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (8R,9R,13R,14R,17R)-17-((R)-1-((2-(dimethylamino)ethyl)amino)ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

    References

    1. Rennhack A, et al. Br J Pharmacol. 2018 May 3. doi: 10.1111/bph.14355.

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