Rivasterat | Endothelial dysfunction blocker

Chemical Structure : Rivasterat

Rivasterat (CU06-1004, Sac-1004)

Catalog No.: PC-25025Not For Human Use, Lab Use Only.

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Biological Activity

Rivasterat (CU06-1004, Sac-1004) is a small molecule vascular leakage blocker and endothelial dysfunction blocker, inhibits endothelial hyperpermeability induced by VEGF, histamine and thrombin via stabilization of cortical actin ring and AJ proteins at the cell-cell junction.
Treatment of Rivasterat (CU06-1004, Sac-1004) in ECs increased cAMP levels and activated Rac, both of which are known to strengthen endothelial barrier.
Rivasterat (CU06-1004, Sac-1004) blocks vascular leakage by enhancing endothelial integrity via the cAMP/Rac/cortactin pathway.
Rivasterat (CU06-1004, Sac-1004) reduces cerebral ischemia-reperfusion injury by suppressing blood-brain barrier disruption and inflammation
Rivasterat (CU06-1004, Sac-1004) inhibited angiogenesis and confirmed vascular stabilization in the oxygen-induced retinopathy model.

Physicochemical Properties

M.Wt	626.83
Formula	C37H54O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (E)-6-((3S,8S,9S,10R,13S,14S,17R)-3-(((2S,5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-5-enoate

References

1. Zhang H, et al. Exp Mol Med. 2022 Jan;54(1):23-34.

2. Noh M, et al. Eur J Pharmacol. 2023 Jan 15;939:175427.

3. Agrawal V, et al. Oncotarget. 2014 May 15;5(9):2761-77.

Rivasterat (CU06-1004, Sac-1004)

Biological Activity

Physicochemical Properties

References

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